SENTERRA II Raman Microscope

The SENTERRA II is a confocal Raman microscope designed for straightforward, non-stop operation. Its high degree of automation allows fast and easy Raman imaging for failure analysis, quality control and scientific research.

Always Calibrated. Maximum Precision.

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Your Raman Microscopy Companion: SENTERRA II

EFFICIENCY FROM SIMPLICITY

Introduction of the SENTERRA II | Product video

Our Raman application scientist presents the SENTERRA II and its features.

The secret to straightforward Raman micoscopy

Automation is the SENTERRA II’s key feature. It allows the user to concentrate on the essential things: the analytical problem, the Raman measurement and more importantly, the results.

SENTERRA II technical features:

Fully automated hardware
One-click switching of 4 built-in lasers
SureCal^TM calibration technology
Fast 3D Raman imaging
Automate your own workflows in minutes
Powerful analysis and identification tools
FT-Raman for minimized fluorescence in
combination with FTIR instrumentation

SENTERRA II provides:

Smooth user experience
Research-grade performance
Superb wavenumber precision
Self-diagnosis and automated OQ/PQ
Virtually maintenance-free operation
100% GMP & 21 CFR p11 compliance

SENTERRA II applications:

Pharmaceuticals
Material Science
Polymers & Plastics
Environmental
Forensics

Reproducibility, Precision and User-Safety in Raman Microscopy

THREE MAJOR DESIGN CHOICES

First, the SENTERRA II is fully automated including self-diagnosis and instrument tests like OQ and PQ. Change a laser by a simple mouse-click and afterwards, filter and grating are adjusted automatically.

Second, to use this automation to its full extent, we rethought calibration and created the patented SureCal^TM technology. It continuously recalibrates the device and allows permanent sub-wavenumber precision.

Third, it’s about user safety – especially when beginners or students are involved. A class 1 laser housing and interlock always protects the user of any harmful laser radiation.

SureCal Continuous Raman Calibration Technology

YOUR ADVANTAGE IN SCIENCE AND INDUSTRY

Naturally, the SENTERRA II offers excellent sensitivity combined with pristine spectral and Raman Imaging performance. But the real powerhouse of this confocal Raman microscope is our SureCal^TM technology.

Let us briefly repeat one of the most important principles of Raman technology: External factors affect the optical and mechanical components in every Raman microscope, especially heat, component changes and vibrations. Ultimately, this induces wavenumber shifts, which must be compensated by regular recalibrations.

Thanks to SureCal^TM, the SENTERRA II is the only Raman microscope that is always calibrated. Don’t waste your valuable time with recalibration – start analyzing. No matter if it is a quick material identification or the collection of large data sets for PCA or other statistical methods.

Dedicate your Raman Microscope to Life-Science

Senterra II can also be configured with an inverted microscope without compromising any functionality. The inverted Raman microscope gives open access for sample handling, which is particularly favorable in characterization of live tissue and cells.

Besides cell research, the inverted microscope also brings advantages in researches like in vitro pharmaceutical verification and in situ Raman measurement that requests better access to the microscopic stage.

Who it’s for? Everyone!

We developed a powerful Raman microscopy platform for all kinds of applications. Its high degree of automation, compact size and efficient workflow, make the SENTERRA II an ideal tool to solve real world tasks in a quality control laboratory or to discover and pioneer in scientific research.

Choose your µ-Raman Application

Art Conservation and Restoration

Historical works of art are precious and to conserve a part of human history is an exciting endeavour. The SENTERRA II is applied in the restoration of historical paintings, buildings and artwork. It offers additional tools like Raman probes and can be mounted on a gantry to cover and analyse larger paintings.

Forensic Science

From the examination of potentially counterfeit art objects to varnish analyses in crime labs. Raman microscopy provides precise information about the chemical identity and origin of unknown substances. Due to the high spatial resolution down to the nanometer range, even smallest secrets are uncovered.

Pharmaceuticals

Early on, Bruker decided address the needs of pharmaceutical companies. Therefore, SENTERRA II and OPUS and are 100% compliant with GMP and all major pharmacopoeias, 21 CFR part 11 and also follow the ALCOA+ principle. Whether locally or on a server, the SENTERRA II ensures the integrity and security of your data.

Polymers and Plastics

Polymers are indispensable and Raman microscopy can provide crucial insights into the quality control and development of plastic products. While Raman imaging yields information on material distribution, dedicated spectral libraries allow the identification of unknown materials and fillers.

Material Science

Whether battery research or studies of graphene or silicon – Raman microscopy is extensively used by material scientists. The SENTERRA II supports you with utmost precision and offers up to three excitation lasers as well as an optional coupling to FT-Raman for minimized fluorescence.

Environmental Studies

One of the many environmental applications is the analysis of microplastics. Again, the high spatial resolution of Raman microscopy offers significant advantages when smallest microplastic (MP) particles needs to be resolved. Automated particle identification routines enable fast and reliable analysis of MP contamination.

SENTERRA II Application Videos

API distribution in a pharmaceutical tablet by Raman microscopy.

Particle Analysis in pharmaceutical manufacturing and quality control by Raman microscopy.

LCD failure analysis within the material by confocal µ-Raman.

Multi layer polymer composite testing and layer determination by SENTERRA II.

How Raman microscopy supports battery research and energy storage.

OPUS Release 8.7 | SENTERRA II | Q3 2021

Highlight: Python Script Interface implemented into OPUS

In OPUS 8.7 SP1, we have made it easier to use customized data processing and evaluation methods with our new Python environment within OPUS. It opens a door for the users who need special algorithms for the data. The python script can be executed in OPUS right after the Raman measurement. Make the post-processing truly yours and enjoy all the power you can bring to the routine measurements with Python.

Highlight: High Performance Chemical Image Generation by New Adaptive K-means Clustering Function

We also released a new Raman data analysis function Adaptive K-means Clustering. It was created with the help of the build-in Python environment. With this new function, you can generate a chemical imaging directly after the measurement without the need of selecting specific Raman peak at all. The system will sort the spectra into groups automatically and generates Raman images all by itself. For the applications that use a known sample, for instance a pharmaceutical tablet with several APIs, this function can provide the user Raman image immediately and save a lot of time. For the experiments of unknown samples, with the automatic Raman imaging method, users can tell at a glance if the sample is homogeneous or structured chemically.

Other new functions availa on SENTERRA II:

“Cluster ID” Function for Identification of Classes in 3D Spectral Data
“Find Particles” function now contains a novel particle detection method
SENTERRA II now operates under new OVP-X routine